Johns Hopkins University, Greater Baltimore's largest employer, spends more than any other university on medical, science and engineering research. Johns Hopkins spent $1.85 billion on this research in fiscal 2009, according to the National Science Foundation, which tracked 711 institutions.
Rounding out the top five were the University of Michigan, University of Wisconsin, Madison; University of California, San Francisco, and University of California, Los Angeles.
You can see the National Science Foundation report
here.